Sterix Limited

Dharshini Ganeshapillai

Michael John Reed

Barry Victor Lloyd Potter

Atul Purohit

Nigel Vicker

Su Xiangdong

Su Xiangdon

A compound having Formula I wherein one of Rand Ris a group of the formula wherein Ris selected from H and hydrocarbyl, Ris a hydrocarbyl group and L is an optional linker group, or Rand Rtogether form a ring substituted with the group wherein Ris H or a substituent, and wherein X is selected from S, O, NRand C(R)(R), wherein Ris selected from H and hydrocarbyl groups, wherein each of Rand Rare independently selected from H and hydrocarbyl groups.

Compound

A compound having Formula IR&#x2014;Z&#x2014;RFormula Iwherein Ris an optionally substituted phenyl ring; Ris or comprises an optionally substituted aromatic ring; and Z is &#x2014;X&#x2014;Y&#x2014;L&#x2014; or &#x2014;Y&#x2014;X&#x2014;L&#x2014; wherein either X is selected from &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014; and &#x2014;C(&#x2550;O)&#x2014;; and Y is &#x2014;NR&#x2014;; or X is selected from &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014; and &#x2014;S&#x2014;, and Y is &#x2014;C(R)(R)&#x2014;; L is an optional linker; and R, Rand Rare each independently selected from H and hydrocarbyl; and wherein when Rcomprises the following structural moiety wherein Q is an atom selected from the group consisting of S, O, N and C; the compound is selected from compounds of the formulae R&#x2014;C(&#x2550;O)&#x2014;NR&#x2014;L&#x2014;R; R&#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;C(R)(R)&#x2014;L&#x2014;R; R&#x2014;S&#x2014;C(R)(R)&#x2014;L&#x2014;R; R&#x2014;NR&#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;L&#x2014;R; R&#x2014;NR&#x2014;C(&#x2550;O)&#x2014;L&#x2014;R; R&#x2014;C(R)(R)&#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;L&#x2014;R; and R&#x2014;C(R)(R)&#x2014;S&#x2014;L&#x2014;R.

11&#x3b2;-hydroxysteroid dehydrogenase inhibitors

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Slough, United Kingdom

Dharshini Ganeshapillai