Bristol-myers Squibb Compnay

Celgene Corporation

Cerep Sa

Dharmpal S Dodd

Christopher P Mussari

Alaric J Dyckman

Sreekantha Ratna Kumar

Laxman Pasunoori

Trevor C Sherwood

Tasir Shamsul Haque

Subramanya Hegde

Shoshana L Posy

Brian K Whiteley

John E Macor

Ramesh Kumar Sistla

David R Tortolani

Brian E Fink

Louis John Lombardo

John L Gilmore

Yufen Zhao

Lalgudi S Harikrishnan

Muthoni G Kamau

Anupama Kandhi Ramachandra Reddy

Srinivasan Kunchithapatham Duraisamy

Michael A Poss

Zheming Ruan

Rushith Kumar Anumula

Ashvinikumar V Gavai

Wayne D Vaccaro

John S Tokarski

Lan-Ying Qin

Pitani Veera Venkata Srinivas

John T Hynes

Daniel O'Malley

Tram N Huynh

Libing Chen

Steven J Walker

John V Duncia

Joseph B Santella

Percy H Carter

Daniel S Gardner

Upender Velaparthi

Mark D Wittman

Ashok Vinayak Purandare

Peiying Liu

Cullen L Cavallaro

Chetan Padmakar Darne

Selvakumar Kumaravel

Dibakar Mullick

Rui-Qin Liu

Durga Buchi Raju Barre

Peter Kinam Park

Ping Chen

T G Murali Dhar

William John Pitts

Stephen T Wrobleski

Chunjian Liu

Matthew David Alexander

Wu Yang

Dehua Huang

Annapurna Pendri

Soong-Hoon Kim

James M Lin

John E Starrett, Jr

Rajeev S Bhide

Derek J Norris

Yong Zhang

Wen-Ching Han

Chongqing Sun

Satheesh Kesavan Nair

Hunter Paul Shunatona

Deborah Mortensen

Kevin W Gillman

Samuel Gerritz

Brandon Wade Whitefield

George V Delucca

John K Dickson

Patrice Gill

Venkatram Reddy Paidi

Shuqun Lin

Michele Launay

Christopher Blair Cooper

Claude A Quesnelle

Dominique Potin

Abhisek Banerjee

Chong-qing Sun

Louis J Lombardo

Chandrasekhar Reddy Rachamreddy

Zhong Chen

Litai H Zhang

Dora M Schnur

Anthony J Sampognaro

Danielle M Bocchino

Giulianna Miseo

Natalie Holmberg-Douglas

Jennifer Griffin

Jayce Rhodes

Tasir Shamsul Hague

Anupama Ramachandra

Subramaya Hegde

Provided herein are compounds and compositions thereof for modulating BCL6. In some embodiments, the compounds and compositions are provided for treatment of cancer or an autoimmune disease.

Modulators of BCL6 as ligand directed degraders

Disclosed are compounds of Formula (I) or salts thereof, wherein R, R, R, R, and Rare defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted carbazole compounds

Disclosed are compounds of Formula (I) (I) N-oxides, or salts thereof, wherein R, G, A, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole ether compounds

Disclosed are compounds of Formula (I) or a salt thereof, wherein R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein A, G, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

6-azaindole compounds

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole compounds useful as TLR inhibitors

4-azaindole compounds

Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole compounds

The present invention is directed to compounds of the formula (I), wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders. 

Cyclic dinucleotides as anticancer agents

Disclosed are compounds of Formula (I) or a salt thereof, wherein: Y is Formula (II), or Formula (III); R, R, R, R, R, R, R, R, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Substituted indole compounds useful as inhibitors of TLR7/8/9

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein A, G, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

N-oxides, or salts thereof, wherein G, L, R, R, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Amide substituted indole compounds useful as TLR inhibitors

Growing community of inventors

Princeton, NJ, United States of America

Dharmpal S Dodd