University of Pennsylvania

Dharmesh R Tailor

Ravinder Reddy

James E Baumgardner

Prior approaches have deliveredOto a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by HO created in non-cerebral tissues. During a brief pulse ofOinhalation, this arterial input function for HO is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation ofOeven more effective. Accordingly, ventilator system are provided to deliverOas a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of HO in the cerebral ventricles, suggesting that the arterial input function of HO is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.

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Voorhees, NJ, United States of America

Dharmesh R Tailor