Madrigal Pharmaceuticals, Inc.

Dharma Vutukuri

Shoujun Chen

Weiwen Ying

Dinesh U Chimmanamada

Jun Jiang

Genliang Lu

Teresa Kowalczyk-Przewloka

Junyi Zhang

Sami Osman

James Loch

The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

Targeted therapeutics

Growing community of inventors

Woburn, MA, United States of America

Dharma Vutukuri