Agenus Inc.

Dhan Sidhartha Chand

Olga Ignatovich

Benjamin Maxime Morin

Nicholas Stuart Wilson

Dennis John Underwood

Marc A Van Dijk

David Adam Savitsky

Cornelia Anne Mundt

Mark Arthur Findeis

Yanping Xiao

Emmanuel Cyrille Pascal Briend

K Mark Bushell

Nicola Anne Ramsay

Spencer Campbell

Beth Wensley

Veronica Franciszka Ilkow

Randi Barbara Gombos

Zahra Jawad

The instant disclosure provides multispecific molecules that specifically bind to CD96 (e.g., human CD96) and/or TIGIT (e.g., human TIGIT) and isolated antibodies that specifically bind to TIGIT (e.g., human TIGIT). Also provided are pharmaceutical compositions comprising these multispecific molecules and antibodies, nucleic acids encoding these multispecific molecules and antibodies, expression vectors and host cells for making these multispecific molecules and antibodies, and methods of treating a subject using these multispecific molecules and antibodies.

Anti-TIGIT and anti-CD96 antibodies

The instant disclosure provides antibodies that specifically bind to CD96 (e.g., human CD96) and antagonize CD96 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Antibodies that specifically bind human CD96

The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-CD137 antibodies and methods of use thereof

The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-TIGIT antibodies and methods of use thereof

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Woburn, MA, United States of America

Dhan Sidhartha Chand