Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Astra Aktiebolag

Aktiebolaget Astra

Dezso Korbonits

Gergely Heja

Pal Kiss

Endre Palosi

Ida Szvoboda Nee Kanzel

Maria Szomor Nee Wundele

Csaba Gonczi

Sandor Virag

Laszlo Ledniczky

Judit Cser Nee Kun

Gabor Kovacs

Gabor T Szabo

Tamas U Kallay

Vera Gergely

Judit Kun

Erzsebet Molnar Nee Bako

Rudolf Szebeni

Katalin Marmarosi Nee Kellner

Gyula Papp

Laszlo Szekeres

Emil Minker

Csaba Gonczy

Kalman Harsanyi

Jozsef Szejtli

Gyula Sebestyen

Laszlo Tardos

Peter S Kormoczy

Csaba Huszar

Mihaly Nogradi

Sandor Antus

Agnes Gottsegen

Karoly Horvath

Vera Kovacs Nee Mindler

Attila Nemeth

Erzsebet Szalay

Karoly Ban

Ferenc Morasz

Istvan Bone

Ferenc Sperber

Laszlo Harsing

Livia Nagy Nee Koranyi

Gyorgy Mihalovics

Sandor Garaczy

Maria Szomor

Gyorgy Simon

Zoltan Vargai

Karol Gyure

Erzsebet Szabo Nee Kardos

Jozsef Knoll

Tamas Szuts

Katalin Marmarosi

Gabor Horvath

Imre Bata

Jeno Marton

Agnes Stadler Nee Szoke

Istvan Turcsan

Lorand Debreczeni

Andras Wolfner

Janos Strelisky

Maria Vikmon Nee Kiraly

Peter Kormoczi

Peter Gyri

Andrea Bolehovszky

Zsuzsa Furst

Agnes Stadler

Peter Gy Ri

Mihaly Sut

Jozsef Szegi

Gabor Kovacz

Borbala Vermes Nee Szluha

Judit Cser

Ida Szvoboda

Csaba Gunczi

Ida Szyoboda Nee Kanzel

Iidiko Buttkai

Andras Kelemen

Gyorgy Kormoczi

Ida Szvoboda Nee Kauzel

Ildiko Buttkai

Katalin Marmarosi Nee Keliner

Ida Szoboda Nee Kanzel

Molnar Leventene

Eva Udvari

Arpad Kvari

Mihaly Su

Arpad K Vari

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

The invention relates to novel diphenylpropylamine derivatives of the general formula (I). ##STR1## R.sup.1 stands for hydrogen or a methyl group; R.sup.2 stands for hydrogen, a methyl or n-decyl group;

Diphenkylpropylamines for the therapy of heart disease

The present invention relates to new compounds of Formula I ##STR1## and physiologically acceptable salts thereof wherein A and B stand for oxygen or --CH.sub.2 group with the proviso that if A stands for oxygen, then B stands for --CH.sub.2 group and R stands for hydrogen and, if A represents a --CH.sub.2 group, then B stands for oxygen, R stands for a --CH.sub.2 Q group wherein Q stands for hydrogen, and pyrrolidino, piperidino or morpholino and a process for the preparation thereof and pharmaceutical compositions containing as active ingredient a compound of the Formula (I) or a physiologically acceptable salt thereof.

Xanthine derivatives

Diuretic and saluretic tetrahydro-isoquinoline derivatives of the Formula (I) ##STR1## wherein R stands for hydrogen or chlorine,

2-amino-tetrahydro-isoquinolene derivatives and a process for the

The present invention relates to novel compounds of the general formula ##STR1## wherein R is hydrogen atom or a trifluoromethyl, carboxy, C.sub.2-5 alkoxycarbonyl, cyano, benzoyl, sulfamoyl or C.sub.1-4 alkylsulfonyl group;

Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides

The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I ##STR1## and pharmaceutically acceptable salts thereof wherein A stands for C.sub.1-4 alkylene and

Oxadiazole-alkyl-purine derivatives useful as antitussive agents

The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, wherein

Process for the preparation of diphenyl ether derivatives

2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R.sup.2' stands for C.sub.1 to C.sub.12 alkyl or a group of the formula ##STR2## in which R.sup.11 is C.sub.1 to C.sub.4 alkyl;

Dibenzo[bd]pyran derivatives, process for the preparation thereof and

A process is disclosed for the preparation of a compound of the formula (XI) ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.3 alkoxy, or trifluoromethyl;

Process for the preparation of 5(6)-thio substituted benzimidazoles

Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,

Theophyllinyl-alkyl-oxadiazoles, process for the preparation thereof and

Process for the preparation of an inclusion complex of

A new process is disclosed for the preparation of a compound of the formula (VIII) ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, or trifluoromethyl;

Production of thiocyanato benzimidazoles

Arylacetic acid derivatives of the formula ##STR1## with R.sup.1, R.sup.2 and R.sup.3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are prepared by catalytic hydrogenation of new compounds of the formula ##STR2## in which R and R.sup.10 are also specifically defined. The method of making the latter compound is also set forth.

Process for the preparation of arylacetic acid derivatives

2-(3-phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

2-Cyano-2-(3-phenoxy-phenyl)-propionic acid amide and preparation thereof

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Budapest, Hungary

Dezso Korbonits