Nanjing Sanhome Pharmaceutical Co., Ltd.

Dezhong Wang

Yong Wang

Xian Zhang

Di Zhang

Liwen Zhao

Cang Zhang

Hongyan Chen

Haiping Zhou

Sheng Bi

Yang Nan

Yiping Gao

Yuxiu Li

A novel nucleoside phosphoramidate compound of the formula below, or a stereoisomer, salt, hydrate, solvate or crystal thereof for the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection, and having a good anti-HCV effect; a pharmaceutical composition having the compound, or a stereoisomer, salt, hydrate, solvate or crystal thereof: 

Nucleoside phosphoramidate compound and use thereof

The present invention belongs to the field of chemical pharmaceuticals, and specifically relates to compounds represented by formula I having a 9,9,10,10-tetrafluoro-9,10-dihydrophenanthrene structure and being able to inhibit hepatitis C virus activity, or a pharmaceutically acceptable salt, isomer, solvate, crystal or prodrug of said compounds, a pharmaceutical composition containing said compounds, and an application of said compounds or composition in the preparation of a drug. The compounds of the present invention have a good HCV inhibitory effect.

9,9,10,10-Tetrafluoro-9,10-dihydrophenanthrene hepatitis C virus inhibitor and application thereof

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Nanjing, China

Dezhong Wang