Fudan University

Deyong Ye

Yong Chu

Lu Zhou

Yan Chen

Yali Li

Qi Huang

Mingguang Mo

Penghui Wang

Haojun Gong

Zhikuan Zhang

Jinyu Fei

Jintong Yang

Xiangyu Qi

Alkoxybenzeno five- or six-member heterocyclic amines compounds, their pharmaceutically acceptable salts, and pharmaceutical compositions are used as the active ingredients, and their application in drugs which can prevent and cure diseases caused by abnormal increasing of SM. These diseases caused by abnormal increasing of SM include atherosclerosis, type II diabetes, fatty liver, obesity, metabolic syndromes, enteritis and other inflammatory diseases.

Alkoxybenzo-five-membered (six-membered) heterocyclic amine compound and pharmaceutical use thereof

2-alkoxy benzene formyl arylamine compounds and their pharmaceutical salts are disclosed. The compounds can act as sphingomyelin synthase (SMS) inhibitors to treat diseases caused by abnormal increasing of sphingomyelin (SM). The pharmaceutically acceptable salts and pharmaceutical compositions of the compounds are used as active ingredients in drugs which can prevent and cure diseases caused by SM level abnormal increase. These diseases include atherosclerosis, fatty liver, obesity, type diabetes, and other metabolic syndromes.

2-alkyloxy benzene formyl arylamine compound and pharmaceutical use thereof

Growing community of inventors

Shanghai, China

Deyong Ye