Bend Research, Inc.

Lovelace Biomedical Research Institute

Devon Dubose

Dwayne Thomas Friesen

David D Newbold

Douglas Lee Millard

John Michael Baumann

James Mathew Mullin

Daniel Elmont Dobry

Steven A Belinsky

Aaron Badenoch

Philip J Kuehl

Michael Burke

An embodiment of the present invention provides for a dry powder pharmaceutical composition suitable for dispersion in an aerosol for inhaled administration to a patient with cancer, the composition comprising: a cytidine analogue including salts, solvates, hydrates, and esters thereof; and a pharmaceutically acceptable excipient together forming the dry powder pharmaceutical composition suitable for dispersion in the aerosol for administration via inhalation to the patient with cancer. Another embodiment provides for a method of making the composition and a further embodiment provides for a method a treating a patient in need thereof with the composition.

Inhalable dry powder cytidine analogue composition and method of use as a treatment for cancer

The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T, wherein Tis greater than T, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T, such that the active agent and matrix material are soluble in the organic solvent at T.

Spray-drying process

A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.

Spray-drying apparatus and methods of using the same

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Bend, OR, United States of America

Devon Dubose