Biological E Limited

Deviprasanna Chakka

Narender Dev Mantena

Mahima Datla

Ramesh Venkat Matur

Rajan Sriraman

Satyam Naidu Sureddi

Rajendar Burki

Mandar Shirish Dixit

Sreenivasa Rao Ganti

Balamurali Masilamani

Sureddisatyam Naidu

The present disclosure relates to multivalent pneumococcal vaccine compositions comprising capsular pneumococcal polysaccharide serotypes each individually conjugated to carrier proteins. When conjugated, the combination of the capsular pneumococcal polysaccharide serotype and the carrier protein is referred to herein as a polysaccharide-protein conjugate. The pneumococcal vaccine compositions may further comprise one or more of the following; a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a buffer, a preservative, a stabilizer, an adjuvant, and/or a lyophilization excipient. Methods of making and administering the pneumococcal vaccine compositions described herein are also provided.

Multivalent pneumococcal vaccine compositions comprising polysaccharide-protein conjugates

The present invention provides an improved method for the production of CRMwith high yield using engineeredstrain having an increased copy number of the CRMgene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.

Method for high level production of CRM

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Telangana, India

Deviprasanna Chakka