Janssen Pharmaceutica Nv

Janssen Pharmaceutica

Rapport Therapeutics, Inc.

Devin M Swanson

Michael Anthony Letavic

Brad M Savall

Chandravadan R Shah

Curt A Dvorak

Brock T Shireman

Akinola Soyode-Johnson

Wenying Chai

Heather Renee Coate

Dale A Rudolph

Christine Fang Gelin

Brice M Stenne

Christa C Chrovian

Manuel Jesus Alcazar Vaca

Jose Ignacio Andres Gil

Meri De Angelis

Michael K Ameriks

Kiev S Ly

Bradley M Savall

Nicholas I Carruthers

Daniel J Pippel

Emily M Stocking

Kathleen C Sappey

Dongpei Wu

Wei Zhang

Gang Chen

Jill A Jablonowski

Suchitra Ravula

Victoria Wong

Akinola Soyode Johnson

Vi T Tran

Cynthia G B Berry

Wei Xiao

Neelakandha S Mani

Xiaohu Deng

Jason Christopher Rech

Brett D Allison

Richard Apodaca

Terry Patrick Lebold

Mark Seierstad

Jessica L Wall

Jimmy T Liang

Jeannie M Ziff

Pascal Bonaventure

Miguel Angel Pena Piñon

David Wei Lin

Fabrice Loic Jourdan

Kathleen C Strother

Cynthia GB Berry

Miguel Angel Pena PIÑÓN

Michael A Letavic

Richard L Apodaca

Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.

Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).

Azabenzimidazoles and their use as AMPA receptor modulators

The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.

P2X7 modulators

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof,  Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).

The present invention is directed to compounds of Formulas (I, IIa and IIb):  The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.

Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators

Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions, comprising compounds of Formula (I), and methods of using compounds of Formula (I).

Indolone compounds and their use as AMPA receptor modulators

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof,  Also provided herein are pharmaceutical compositions, comprising compounds of Formula (I), and methods of using compounds of Formula (I).

Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators

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Carlsbad, CA, United States of America

Devin M Swanson