Edwards Lifesciences Corporation

Devin H Marr

Glen Thomas Rabito

Minh T Ma

David Mark Taylor

Dustin P Armer

Christopher J Olson

Alison S Curtis

Kevin M Stewart

Hiroshi Okabe

Philip P Corso, Jr

Eric Robert Dixon

Sergio Delgado

Asher L Metchik

Matthew T Winston

Cheng-Tung Huang

Amanda Kristine Anderson White

Tam Van Nguyen

Victoria Cheng-Tan Wu

Stanton J Rowe

Alexander J Siegel

Emil Karapetian

Robert C Taft

Seung-Beom Yi

Yoon Hee Kwon

Sam Sok

Matthew A Peterson

Grant Matthew Stearns

Erin M Spinner

Ryan Silva

Rhayoung Kwon

Mark Huang

Philip P Corso

Prosthetic heart valve assemblies and methods, apparatus, and systems used to deliver a prosthetic heart valve assembly. A prosthetic heart valve assembly includes an inner frame, a prosthetic leaflet section disposed within the inner frame extending between in inflow row of cells and an outflow row of cells of the inner frame, and an outer support stent. The inner frame is disposed within the outer support stent, and the outer support stent is coupled and/or fastened to the inner frame. The outer support stent includes a plurality leaflet capturing arms for capturing native leaflets between the leaflet capturing arms and a portion of the prosthetic heart valve assembly when the prosthetic heart valve assembly is implanted in a native valve. For example, the native leaflets can be frictionally secured between the leaflet capturing arms of the support stent and the inner frame.

Retaining mechanisms for prosthetic valves

A valve repair delivery handle includes a housing, an actuation control mechanism, and a clasp control mechanism. The actuation control mechanism includes a knob and an actuation tube. The knob is rotatably coupled to the housing. The actuation tube is coupled to the knob such that rotation of the knob in a first direction moves the actuation tube distally relative to the housing and rotation of the knob in a second direction moves the actuation tube proximally relative to the housing. The clasp control mechanism is coupled to the housing.

Valve repair delivery handle

Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support-structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.

Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve assembly. In embodiments, a prosthetic heart valve assembly, including a self-expandable support structure and a self-expanding heart valve, are advanced through the aortic arch of a patient using a delivery system. The support structure, which includes a plurality leaflet retaining arms, is at least partially expanded and positioned on or adjacent to the outflow side of the aortic valve. The prosthetic heart valve is positioned in the aortic valve. The prosthetic heart valve is expanded while it is within an interior of the support structure and while the support structure is positioned on or adjacent to the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the arms of the support structure and the expanded prosthetic heart valve.

An implantable prosthetic device can include a spacer member, a plurality of anchors, and a plurality of clasps. The spacer member can be configured to be disposed between native leaflets of a heart. The anchors can be coupled to the spacer member and configured to secure the native leaflets against the spacer member. The clasps can be coupled to a respective anchor and configured to secure the native leaflets to the anchors. The clasps can be independently movable between an open configuration and a closed configuration.

Mitral valve spacer device

A delivery system includes an elongate shaft, a handle, a first clasp control member, and a second clasp control member. The handle is connected to a proximal portion of the elongate shaft. The first and second clasp control members each extend into a distal portion of the elongate shaft, through at least a portion of the elongate shaft, out of the proximal portion of the elongate shaft, and through the handle. The first and second clasp control members have paths that include a first parallel portion in the elongate shaft where the first clasp control member and the second clasp control member are parallel, and a diverging portion that is proximal to the first parallel portion where the first clasp control member diverges from the second clasp control member.

Valve repair device

An implantable heart valve device has a main body including a first end portion and a second end portion. The main body is configured to be implanted around a native leaflet of a heart valve such that the first end portion is on an atrial side of the leaflet and the second end portion is on a ventricular side of the leaflet, and such that the main body can coapt with an opposing native leaflet during operation of the heart valve. One of the first or second end portions comprises a coupling assembly, and the other of the first or second end portions comprises a coupling member configured to extend through the native leaflet when the heart valve device is implanted in a heart valve. The coupling assembly is configured to releasably engage the coupling member to permit adjustment of the relative positions of the first and second end portions.

Adjustable and reversible locking mechanism for catheter-delivered implant

A delivery system includes an elongate shaft, a handle, a first clasp control member, a second clasp control member, and an actuator. The handle is connected to a proximal portion of the elongate shaft. The first and second clasp control members each extend into a distal portion of the elongate shaft, through at least a portion of the elongate shaft, out of the proximal portion of the elongate shaft, and through the handle. The actuator is coupled to the handle and has a first side portion connected to the first clasp control and a second side portion connected to the second clasp control. The first side portion and the second side portion are releasably couplable such that when the first side portion and the second side portion are coupled, proximal movement of the actuator proximally pulls both the first clasp control member and the second clasp control member, and such that when the first side portion and the second side portion are uncoupled, individual proximal movements of the first side portion and the second side portion independently pull the first clasp control member and the second clasp control member, respectively.

Representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve are disclosed. In one embodiment, for instance, a support structure and an expandable prosthetic valve are delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support-structure interior) via a delivery system. The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable, prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.

Methods for delivering prosthetic valves to native heart valves

Implementations of the tissue illumination systems, devices, and methods disclosed herein take advantage of the translucent nature of tissue to reveal properties by light transmission, for example, tissue type, tissue transition locations, underlying structures, and the like, that are not easily distinguished by reflected light. Illuminating a back-side of a translucent tissue permits a user to distinguish between different types of tissue, tissue transition locations, and/or structures that are difficult or impossible to discern under overhead or front-side illumination. Implementations include a light source that is positionable behind a tissue or disposable within a body cavity or duct, for example, within a heart ventricle.

Tissue illumination system, device, and method

Embodiments of an apparatus, and a method for crimping expandable stents or prosthetic valves having a radially expandable and compressible annular body and one or more protruding anchors extending from the body using the apparatus, where the apparatus comprise a housing, a plurality of circumferentially arranged nesting jaws, and an actuator configured to move the jaws radially inwardly to reduce the size of the crimping aperture, thereby radially compressing the annular body of the prosthetic valve or stent. In particular embodiments, a selected set of the jaws, each having a front side and a recessed portion in its front side adjacent to its inner end. The recessed portions of the selected jaws collectively are sized and shaped to receive the one or more anchors of the prosthetic valve when the annular body is positioned within the crimping aperture.

Growing community of inventors

Irvine, CA, United States of America

Devin H Marr