United States of America, As Represented by the Secretary of Agriculture

Lawrence Livermore National Security, LLC

University of Connecticut

Devendra Rai

Aida Elizabeth Rieder

Paul D Hoeprich

Luis Leandro Rodriguez

Teresa B De Los Santos

Fayna C Diaz-San Segundo

William M Fischer

Genetically engineered Foot and Mouth Disease Virus (FMDV) and related engineered proteins and polynucleotides, nanolipoprotein particles, compositions, methods and systems are described. The genetically engineered FMDV is modified by the strategic insertion of a protein tag into select regions of the FMDV genome which encode viral proteins that are exposed on the surface of the FMDV viral capsid. The inserted protein tag is displayed as a decoration or attachment on the viral capsid surface.

Genetically engineered foot and mouth disease virus and related proteins, polynucleotides, compositions, methods and systems

Genetically engineered Foot and Mouth Disease Virus and related proteins, polynucleotides, compositions, methods and systems

Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. The mosaic polypeptides have greater T-cell epitope coverage than naturally occurring FMDV polypeptides, and include common FMDV epitopes, but exclude rare FMDV epitopes. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype A FMDV strains.

Mosaic vaccines for serotype a foot-and-mouth disease virus

Growing community of inventors

Old Saybrook, CT, United States of America

Devendra Rai