Schering Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Bayer Intellectual Property Gmbh

Piramal Imaging Sa

Detlev Suelzle

Johannes Platzek

Philip Lienau

Markus Berger

Christoph-Stephan Hilger

Olaf Panknin

Gregor Jost

Hanns-Joachim Weinmann

Ulf Bömer

Hartmut Rehwinkel

Stefan Jaroch

Margrit Hillmann

Gerardine Anne Burton

Iris Pribilla

Heribert Schmitt-Willich

Ulrich Niedballa

David D Davey

Knut Eis

Thomas Frenzel

Bernd Raduechel

Ludwig Zorn

Roland Neuhaus

Volker Schulze

Thomas Brumby

Wolfgang Ebert

Andrea Hägebarth

Kirstin Petersen

Bernd Misselwitz

Thorsten Blume

Timo Stellfeld

Lutz Lehmann

Hubertus Pietsch

Jessica Lohrke

Mathias Berndt

Ludger Dinkelborg

Joseph S Beckman

Wolfgang Schlecker

Peter Holscher

Norman Koglin

Peter H&ouml;lscher

Ananth Srinivasan

Fiona Mcdonald McDonald

Peter Hoelscher

Gisbert Depke

Florian Pühler

Matthias Friebe

Thomas Fenzel

Myléne Karramkam

An aqueous pharmaceutical composition including compound having the formula of tetragadolinium [4,10-bis(carboxylatomethyl)-7-{-3,6,12,15-tetraoxo-16-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]-9,9-bis({[({2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propanoyl}amino)acetyl]amino}methyl)-4,7,11,14-tetraazaheptadecan-2-yl}-1,4,7,10-tetraazacyclododecan-1-yl]acetate wherein the stereochemistry at the chiral carbon of the four alanine substituents is selected from the group consisting of RRRR, SSSS, RSSS, RRSS, and RRRS stereoisomers, and racemic and diastereomeric mixtures of any thereof, or a tautomer, a hydrate, a solvate, or a salt thereof, or a mixture of same is described. The compounds may be used as an MRI contrast imaging agent.

Gadolinium chelate compounds for use in magnetic resonance imaging

A compound having the formula of tetragadolinium [4,10-bis(carboxylatomethyl)-7-{-3,6,12,15-tetraoxo-16-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]-9,9-bis({[({2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propanoyl}amino)acetyl]amino}methyl)-4,7,11,14-tetraazaheptadecan-2-yl}-1,4,7,10-tetraazacyclo dodecan-1-yl]acetate wherein the stereochemistry at the chiral carbon of the four alanine substituents is selected from the group consisting of RRRR, SSSS, RSSS, RRSS, and RRRS stereoisomers, and racemic and diastereomeric mixtures of any thereof, or a tautomer, a hydrate, a solvate, or a salt thereof, or a mixture of same is described. The compounds may be used as an MRI contrast imaging agent.

A compound having the formula of tetragadolinium [4,10-bis(carboxylatomethyl)-7-{-3,6,12,15-tetraoxo-16-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]-9,9-bis({[{2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]propanoyl} amino)acetyl]amino}methyl)-4,7,11,14-tetraazaheptadecan-2-yl}-1,4,7,10-tetraazacyclo dodecan-1-yl]acetate wherein the stereochemistry at the chiral carbon of the four alanine substituents is selected from the group consisting of RRRR, SSSS, RSSS, RRSS, and RRRS stereoisomers, and racemic and diastereomeric mixtures of any thereof, or a tautomer, a hydrate, a solvate, or a salt thereof, or a mixture of same is described. The compounds may be used as an MRI contrast imaging agent.

The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.

Aromatic sulfonamides as peroxynitrite-rearrangement catalysts

Compounds of formula I, their tautomeric and isomeric forms and salts,as well as the process for their production and their use in pharmaceutical agents are described.

Benzoxazine and benzothiazine derivatives and the use thereof in medicaments

The invention relates to macrocyclic perfluoroalkylamides, their production and their use in diagnosis.

Perfluoroalkylamides, their production and their use in diagnosis

Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.

Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals

Substituted heterocycles and their use in medicaments

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Berlin, Germany

Detlev Suelzle