Schering Aktiengesellschaft

Kali-chemie Aktiengesellschaft

Solvay Enzymes Gmbh & Co. Kg

Gesellschaft Fuer Biotechnologische Forschung Mbh

Gesellschaft Fuer Bio-technologische Forschung

Detlef Wilke

Roman Vetter

Alfred Weber

Ingo Muecke

Bernhard Moeller

Gerhard Konieczny-Janda

Wolfgang Aehle

Dietmar Schomburg

Andre Clippe

Meike Takenberg

Martina Mueller

Mario Kennecke

Antoine Amory

Klaus-Guenter Gerling

Johannes Kurzidim

Birgit Foullois

Amory Antoine

Harald Sobek

Alkaline Bacillus proteases, their use and a method for producing these proteases are described. These are in particular Bacillus proteases from Bacillus pumilus DSM 5777. The alkaline proteases according to the invention are suitable for use in compositions for cleaning and washing purposes.

Alkaline proteases from Bacillus pumilus

Enzymes stabilized against the destabilizing effect of ionic surfactants and a method of producing such stabilized enzymes in which DNA sequences which code for the enzymes are modified by directed mutation in defined positions which correlate with defined surface regions of the enzyme, in such a way that the codon in which the mutation is located now codes for an amino acid differing from the original amino acid.

Stabilized enzymes and process for preparing them

Alkaline bacillus lipases, coding DNA sequences therefor and bacilli,

Novel, optimized highly alkaline proteases which are suitable for use in detergent formulations are prepared by employing microorganisms transformed by mutated DNA sequences. The mutated sequences are obtained starting from DNA sequences which code for highly alkaline protease usually produced by Bacillus species by altering these DNA sequences in defined positions by directed mutagenesis (point mutation) in such a way that the codon in which the point mutation is located now codes for an amino acid which is more strongly basic than the original amino acid. The result is highly alkaline proteases in which original amino acids have been replaced by more strongly basic amino acids, preferably by the amino acids lysine or arginine. Synthetic oligonucleotides, DNA sequences, vectors and transformed microorganisms which are used for generating and obtaining the optimized highly alkaline protease are also described.

Highly alkaline proteases

Washing and detergent composition are described which contain surfactants, optional bleaching agents and other conventional constituents of washing and detergent compositions, and also lactobionic acid and/or lactobionic acid salts as biodegradable and ecologically acceptable washing agent builders.

Washing or detergent composition containing lactobionic acid or

Process for the preparation of chanoclavine

Process for the preparation of festuclavine

A process for the extraction of aromatic (e.g., phenyl-containing) amino acids from an aqueous phase (solution) containing them, comprising combining the aqueous phase with a tenside of the formula

Process for the extraction of amino acids from an aqueous phase

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Wennigsen, Germany

Detlef Wilke