Diasys Diagnostic Systems Gmbh

Detlef Thônges

Matthias Grimmler

Pia Schu

Carolin Menzenbach

Laura Kreckel

A method for quantitatively determining the amount of acetaminophen in a sample with greater precision, greater sensitivity and fewer interactions and fewer spectral and chemical interferences with other compounds contained in the sample. The method includes acetaminophen being hydrolyzed and the resulting p-aminophenol being reacted with a compound of general formula (III): in the presence of an oxidant to form a compound of general formula (IV): wherein R1 and R2, independently of one another, are selected from H, —CH, and —OCH, R3 is —CHand R4 is a Calkyl moiety with a terminal sulfonate group, with the proviso that at least one of R1 and R2 is —OCHand/or R4 additionally has at least one OH substituent, and then the amount of the compound of general formula (IV) in the reaction mixture being photometrically determined.

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Limburg, Germany

Detlef Thônges