Boehringer Mannheim Gmbh

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Detlef Thym

Peter Vogel

Walter Rittersdorf

Michael Fritz

Wolfgang-Reinhold Knappe

Rainer Schmuck

Zhixin Shao

Peter Kratzsch

Robert Lorenz

Helmut Leininger

Dan Mosoiu

Daniela Beck

Werner Guethlein

Jeffrey N Roe

Karl Miltner

Rudolf Pachl

Hartmut Merdes

Franz Bolduan

Bernd Eisenbarth

Wofgang-Reinhold Knappe

Daniela Bunk

A medical system and method to operating the medical system is presented. A patient storage element is assigned to a patient comprising identification information identifying the patient. A medical device has a contaminating patient application. A medical device storage element on the medical device comprises use information. A clearing device receives the identification information from the patient storage element and the use information from the medical device storage element and analyzes the use information. If in analyzing the use information it is found that application of the medical device to the patient is allowed, a clearance signal is outputted. If in analyzing the use information it is found that application of the medical device to the patient is not allowed, the identification information is analyzed. If in analyzing the identification information it is found that application of the medical device to the patient is allowed, a clearance signal is outputted.

Medical system and method for operating a medical system

A body fluid testing device includes a test strip, an incision forming member, and a housing. The test strip includes an expression surface. In addition, the test strip is attached to the housing to form a cavity, and the cavity slidably receives the incision forming member. The body fluid testing device is positioned over the incision site where the incision forming member makes an incision. The user presses the expression surface against the skin to express body fluid. The cavity collects body fluid via capillary action, and the test strip analyzes the body fluid.

Disposable lancet and lancing cap combination for increased hygiene

The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.

Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase

Analytical system for evaluating test elements having means of determining whether a sufficient amount of sample liquid was evenly applied to an application zone comprising in a first embodiment of the invention at least two sources of light which illuminate separate or at least not fully overlapping areas of the application zone or the evaluation zone of the test strip, a control unit with which the light sources, of which there at least two, can be independently activated, at least one sensor which detects light reflected by the evaluation zone or transmitted by the evaluation zone and supplies an output signal proportional to the intensity of light as well as an evaluation unit which receives a first output signal from the sensor and converts it into a first measured value when the first of the light sources is activated, receives a second output signal from the sensor and converts it into a second measured value when the second of the light sources, is activated and compares the measured values and determines whether the deviation of the first value measured from the second value measured is sufficiently small. In a second embodiment of an analytical system according to the invention, at least one light source is used to illuminate the sample application zone or the evaluation zone of a test element and at least two sensors detect light reflected or transmitted by the evaluation zone, the output signal of the sensors being converted into measured values by the evaluation unit which determines whether the deviation of the measured values is sufficiently small.

Analytical system with means for detecting too small sample volumes

The present invention concerns a diagnostic test carrier for the determination of an analyte from whole blood with the aid of a reagent system contained in the carrier which includes a colour forming reagent with a test field which has a sample application side onto which the blood sample is applied and a detection side on which an optically detectable change takes place as a result of the reaction of analyte with the reagent system and which is constructed in such a way that erythrocytes present in the sample do not reach the detection side, which is characterized in that the test field comprises a transparent foil onto which a first and a second film layer are applied on top of one another and wherein the first layer located on the transparent foil scatters light considerably less in a wet state than the overlying second layer and wherein the side of the foil on which the first layer is applied which is opposite to the foil side is the detection side and the side of the second layer which is opposite to the side with which the second layer rests on the first is the sample application side. In addition the invention concerns a method for the determination of an analyte from whole blood with the aid of a diagnostic test carrier according to the invention.

Diagnostic test carrier with multilayer field

The present invention concerns a diagnostic test carrier (1) containing a supporting layer (2) with a detection layer (3) arranged thereon containing the reagents required to determine analyte in a liquid sample and a network (4) covering the detection layer (3) which is larger than the detection layer (3) and which is attached to the supporting layer (2), which is characterized in that the network (4) is hydrophilic but not capillary active on its own and an inert cover (5) made of sample-impermeable material is arranged over the areas (6) of the network that extend beyond the detection layer in such a way that a sample application site (7) remains free on the region of the network (4) covering the detection layer as well as the use of such a test carrier for the determination of analyte in a liquid. In addition the invention concerns a method for the determination of an analyte in a liquid sample with the aid of a test carrier according to the invention.

Volume-independent diagnostic test carrier and methods in which it is

A test carrier for the determination of ions containing a test layer which has a liquid-resistant, organic phase which contains a hydrophobic polymer in a homogeneous mixture with a hydrophobic, organic liquid of low volatility and an ionophore, as well as a substance which changes its colour in the presence of the ion to be determined. The test carrier is characterized in that the test layer contains particles with an oil number of 80-200 and the ionophore is homogeneously dispersed in the hydrophobic, organic phase. A second test layer contains a buffer capable of maintaining the pH therein at a value of between 5-10.

Test carrier for the determination of ions

The invention relates to a method for determining an ion in an aqueous sample. The method involves contacting the sample with a water immiscible material including an ionophore, a pH indicator and a compound which stabilizes sensitivity of the assay. The ion reacts with the ionophore in the water immiscible material, releasing a proton which reacts with the pH indicator generating a color change which is representative of the ion to be measured. The stabilizing compound stabilizes this change. Also described are compositions including the three recited elements, and various new compounds useful as the stabilizer.

Method for the determination of an ion with increased sensitivity, use

The invention concerns a test carrier for the determination of ions containing a test layer which has a liquid-resistant, organic phase which contains a hydrophobic polymer in a homogeneous mixture with a hydrophobic, organic liquid of low volatility and an ionophore, as well as a substance which changes its colour in the presence of the ion to be determined. The test carrier is characterized in that the test layer contains particles with an oil number of 80-200 and the ionophore is homogeneously dispersed in the hydrophobic, organic phase.

The subject matter of the present invention are naphthol derivatives having the general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 are the same or different and each represents hydrogen, an alkyl or alkoxy group, in which at least one of the residues is a (C.sub.8 -C.sub.30)-alkyl or alkoxy residue

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Mannheim, Germany

Detlef Thym