Cohera Medical, Inc.

Despina Dobbins

Dottie M Clower

Scott Scheeser

Stephanie Kladakis

Patrick Daly

Dottie Clower

A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (RRR)&#x2014;Si&#x2014;CH&#x2014;Z where (i) Z is an &#x2014;OH, &#x2014;SH, &#x2014;NCO, or &#x2014;NHRgroup, where Ris hydrogen, an alkyl group, or an aryl group; and (ii) each R, R, and R, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R, R, and Rare alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.

Silane-containing moisture-curable tissue sealant

Devices for and methods that can be used in endoscopic surgery, and more particularly, devices and methods that can be used for endoscopically applying surgical sealants and other fluids to internal organs and tissues.

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Gibsonia, PA, United States of America

Despina Dobbins