Smithkline Beecham Corporation

Glaxo Group Limited

Other

Pfizer Corporation

Pliva-istrazivacki Institut

Desmond John Best

Barry S Orlek

John Hargreaves Bateson

Brian Charles Gasson

David Richard Witty

Gordon Bruton

George Burton

David John Payne

Robert John Sheppard

Andrew Keith Forrest

Neal Frederick Osborne

John Stephen Elder

Andrea Fajdetic

George R Burton

Martin Leonard Gilpin

Sing Yeung Mak

Graham Walker

Pamela Joan Theobald

Brian Peter Clarke

Geracimos Rassias

Barry Sidney Orlek

The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human. The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.

Piperazine derivative having affinity for the histamine H3 receptor

Macrolones&#x2014;amino substituted quinolones

The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

Bicyclic benzamide compound as histamine H3 receptor ligand useful in the treatment of neurological diseases

There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclizing a compound of Formula (III): wherein R, R, R, R, X and m have meanings which are given in the description.

Process for the preparation of cephalosporin compounds and synthetic intermediates

A compound of formula (I): useful in the treatment and prophylaxis of conditions mediated by s-CD23 

Quinoline derivatives, process for preparing them and use for the treatment of diseases mediated by s-CD23

A compound of formula (I) useful in the treatment and prophylaxis of conditions mediated by s-CD23

Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies

A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a &bgr;-lactam antibiotic, a therapeutically effective amount of an amino acid derivative or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof.

Pyrrolidine and thiazole derivatives with metallo-beta-lactamase inhibitory properties

Beta-thiopropionyl-amino acid derivatives and their use as

.beta.-thiopropionyl-aminoacid derivatives and their use as

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Harlow, United Kingdom

Desmond John Best