Amunix Pharmaceuticals, Inc

Desiree Thayer

Volker Schellenberger

Fan Yang

Bee-Cheng Sim

Chia-Wei Wang

Vladimir Podust

John Beaber

The present invention relates to activatable recombinant polypeptide compositions comprising a cleavage release segment. In some instances, the activatable recombinant polypeptide compositions include an XTEN linked to binding moieties by cleavable release segments that, when cleaved, the binding moieties are capable of binding together effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable activatable recombinant compositions.

Release segments and binding compositions comprising same

The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.

Chimeric polypeptide assembly and methods of making and using the same

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Burlingame, CA, United States of America

Desiree Thayer