Sunshine Lake Pharma Co., Ltd.

Desheng Huangfu

Siegfried Goldmann

Yingjun Zhang

Qingyun Ren

Xinchang Liu

Liang Chen

Zhifu Zou

Guanghua Yan

Jinsheng Liang

Chenliang Wu

This invention relates to L-tartaric acid complexes, acid addition salts, base addition salts of the compound named (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl) morpholine-3-carboxylic acid or tautomer thereof and pharmaceutical compositions thereof, and further relates to use of the compounds or the pharmaceutical compositions in the manufacture of a medicament, especially for use in preventing, managing, treating or lessening a HBV infection. The complex, acid addition salt or base addition salt of the present invention is crystalline form, substantially crystalline form, polymorphism, amorphism, hydrate or solvate.

Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals

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Dongguan, China

Desheng Huangfu