Brantford Chemicals Inc.

University of Alberta

Acic (canada) Inc.

Terochem Laboratories Limited

Derrick L Clive

Gamini Weeratunga

Stephen E Horne

Keshava Ks Murthy

Derek John Norris

Kammaralli S Murthy

Philip L Wickens

Andrew G Wee

A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: ##STR1##

Commercial process for the manufacture of fluconazole and intermediates

Cis vicinal diols are converted to olefins using tellurides or selenide reagents. The diol is reacted to convert the hydroxyl groups into good leaving groups for nucleophilic substitution. Alkyl and aryl sulfonate groups such as mesylate or tosylate are preferred. The product is then reacted with a source of Te.sup.2- or Se.sup.2- ions, preferably an alkali metal telluride or selenide, to form the desired olefin. The process is particularly useful for generating 2',3'-unsaturation in the sugar moiety of nucleosides. Novel intermediate mesylate, tosylate and olefin derivatives of nucleosides are also provided.

Deoxygenation of cis vicinal diols to make didehydro dideoxy

Processes of synthesizing compounds of the formula: ##STR1## wherein R.sub.1 is H, lower alkyl (1 to 6 C), lower dialkyl (1 to 6 C), lower cycloalkyl (3 to 7 C), or lower dicycloalkyl (3 to 7 C);

Synthesis of cholesterol-lowering agents

Growing community of inventors

Edmonton, Canada

Derrick L Clive