Five Prime Therapeutics, Inc.

Derrick Houser

David Bellovin

Nels P Nielson

Kathy Miller

Maike Schmidt

Luis Borges

Majid Ghoddusi

Charles Kaplan

Gloria Brattich

Felicia Kemp

The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.

B7-H4 antibodies and methods of use thereof

Growing community of inventors

San Francisco, CA, United States of America

Derrick Houser