William Marsh Rice University

Derek Rhoades

Kyriacos Costa Nicolaou

Sotirios Totokotsopoulos

Manas R Pattanayak

Manjunath Lamani

Yanping Wang

Soundarapandian M Kumar

In one aspect, the present disclosure provides analogs of thailanstatin of the formula wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. 

Derivatives of thailanstatin A, methods of treatment and methods of synthesis thereof

In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided. 

Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof

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Derek Rhoades