University of Sussex

Cyclacel Limited

Derek N Woolfson

John Colyer

Maya J Pandya

John Walshaw

Joanne Lightowler

Maxim Gennadievich Ryadnov

The present invention relates to a fiber-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of forming protein structures using the fiber-shaping peptides of the present invention.

Fiber-shaping peptides capable of interacting with self-assembling peptides

This invention relates to protein fibre formation and in particular to methods of producing protein fibres to form a protein structure comprising a plurality of first polypeptide units arranged in a first polypeptide strand and a plurality of second polypeptide units arranged in a second polypeptide strand, the strands preferably forming a coiled coil structure, and in which a first polypeptide unit in the first strand extends beyond a corresponding second polypeptide unit in the second strand in the direction of the strands.

Protein structures and protein fibres

The invention provides a method to screen for a modulator of enzymatic activity comprising the step of monitoring the association or dissociation of a pair of polypeptides which can associate as a dimer. The polypeptide pair comprises a first polypeptide comprising detection means and a site of post-translational modification and a second polypeptide comprising detection means.

Compositions and methods for screening for modulators of enzymatic activity

This invention relates to protein fiber formation and in particular to methods of producing protein fibers to form a protein structure comprising a plurality of first polypeptide units arranged in a first polypeptide strand and a plurality of second polypeptide units arranged in a second polypeptide strand, the strands preferably forming a coiled coil structure, and in which a first polypeptide unit in the first strand extends beyond a corresponding second polypeptide unit in the second strand in the direction of the strands.

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Brighton, United Kingdom

Derek N Woolfson