Genomatica, Inc.

Reg Life Sciences, LLC

Ls9, Inc.

Derek L Greenfield

Zhihao Hu

Eli S Groban

Vikranth Arlagadda

Elizabeth J Clarke

Andreas W Schirmer

Baolong Zhu

Sungwon Lee

Xuezhi Li

Behnaz Behrouzian

Donald Eugene Trimbur

Cindy Chang

Kevin Holden

Jessica Winger

Louis G Hom

Fernando A Sanchez-Riera

Noah Helman

Bernardo M Da Costa

Tarah S Baron

Grace J Lee

Scott Allen Frykman

Kseniya Zakharyevich

Fernando A Sanchez-riera

Elizabeth Clarke

The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

Acetyl-CoA carboxylase variants

The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.

Methods and compositions for improved production of fatty acids and derivatives thereof

The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.

Production of fatty acid derivatives

The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.

Car enzymes and improved production of fatty alcohols

Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.

Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells

Growing community of inventors

South San Francisco, CA, United States of America

Derek L Greenfield