The Ohio State University

Other

University of Michigan

Ohio State Innovation Foundation

Derek James Hansford

Arthur J Epstein

Tejal Ashwin Desai

Matthias Essenpreis

Mauro Ferrari

L James Lee

Anthony A Boiarski

Stephen E Feinberg

Daniel Gallego-Perez

Jeremiah J Schley

Robbie J Walczak

Jingjiao Guan

Yanyin Yang

Disclosed are devices for the controlled handling and delivery of solutions, as well as methods of making and using thereof. The devices can comprise a nanoporous membrane having a top surface and a bottom surface; a fluid source positioned in fluid contact with the bottom surface of the nanoporous membrane; and an electrode patterned on one or more of the surfaces of the nanoporous. membrane (e.g., on the top surface of the nanoporous membrane, on the bottom surface of the nanoporous membrane, or on both the top surface and the bottom surface of the nanoporous membrane). The electrode or electrodes are patterned so as to define a fluid delivery region in fluid contact with the top surface of the nanoporous membrane.

Electroosmotic devices for fluid handling

The present invention is generally directed to a method for regulating cellular and tissue physiology, a device for practicing the method, and a process for fabricating the device. In general the process comprises the steps of providing at least one patterned electrode, providing a least one cell, placing the at least one electrode in electrical communication with the at least one cell, and applying a voltage to the electrode thereby delivering an effective amount of a patterned electric field or current thus regulating the physiology and/or growth of the at least one cell.

Electrical stimulation of cell and tissue growth with two-and three-dimensionally patterned electrodes

A nanopump for pumping small volumes of electrolyte solution under the control of a voltage source is described. The device includes a chamber and a nanopore membrane which partitions the chamber into upstream and downstream regions. When a voltage potential is applied across the membrane, electroosmotic flow through the membrane channels produces a precise-volume flow between the two chamber regions. A method for precise-volume pumping employing the nanopump and a nanopump device for determining the lengths of nucleic acid fragments in an electrolyte solution of different-length fragments are also described.

Nanopump devices and methods

A method for forming three-dimensional polymeric particulate microstructures through self-folding of thin-film microparticles. Self-folding of two-dimensional polymeric precursors produces various three-dimensional particulate microstructures. Dumpling-like microstructures with oil cores and polymer coats are prepared by an interfacial-tension driven self-folding method. Roll-like and bowl-shaped hydrogel microstructures are fabricated by self-folding induced by differential volume shrinkage. Curled microstructures are produced by self-folding that is the result of a two-polymer or bilayer method wherein one of the polymers is a volume changeable polymer.

Self-folding polymer microparticles

An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.

Implantable analyte sensor

Growing community of inventors

Columbus, OH, United States of America

Derek James Hansford