Cerus Corporation

Baxter International Inc.

Cynata Therapeutics Limited

Fenwal, Inc.

Derek J Hei

George D Cimino

Michael S Clarke

Mahmood Mohiuddin

Peyton S Metzel

Serge De Gheldere

Igor I Slukvin

Diana Drier

Yuanpang Samuel Ding

Daniel R Boggs

Daniel F Bischof

Shmuel Sternberg

James Laird

Robin Gail Pauley

Robert E Herman

Veronique Mayaudon

Donna L McLarty

Joseph S Moore

Gene Uenishi

Gregory Soudant

George D Dimino

Daniel Baxter SA Lecour

The invention relates to a method for detecting residual, undifferentiated pluripotent stem cells (PSCs) in a culture of cells differentiated from PSCs, the method comprising:

Pluripotent stem cell assay

The invention relates to a method for producing a mesenchymal stem cell (MSC), the method comprising culturing a primitive mesoderm cell in a mesenchymal colony forming medium (M-CFM) comprising LiCl and FGF2, but excluding PDGF, under normoxic conditions for sufficient time for a mesenchymal colony to form, and culturing the mesenchymal colony adherently to produce the MSC, wherein the MSC has superior T-cell immunosuppressive properties relative to an MSC not produced in said M-CFM. The invention also relates to an MSC produced by the method, a population of MSCs produced by the method, a therapeutic composition comprising the MSC produced by the method, an M-CFM and an M-CFM in concentrated form, and method and uses of the MSC or population in treating a disease.

Colony forming medium and use thereof

Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 100 &#x3bc;m to about 1500 &#x3bc;m. The device can be used to adsorb and remove a pathogen-inactivating compounds from a biological composition such as a blood product.

Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix

Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid treatment chamber. A drawer for holding containers of biological fluid introduces the containers into the chamber. Containers for holding the biological fluid are marked by the apparatus to indicate the status of the treatment.

Processing set and methods for processing and treating a biological fluid

Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix.

Removing compounds from blood products with porous particles immobilized in a matrix

Processing set for processing and treating a biological fluid

Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 1 &#x3bc;m to about 200 &#x3bc;m. The matrix can be fibrous, and the particles can have a surface area greater than 750 m/g and a pore diameter between about 25 and 800 &#x212b;. The device can be used to adsorb and remove a pathogen-inactivating compound that is a nucleic acid-binding compound such as psoralen, an acridine derivative or a dye from a biological composition such as a blood product.

Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix

Methods and devices for the removal of psoralens and psoralen photoproducts from blood products are described. The methods include contacting a psoralen- and irradiation-treated blood product with a resin capable of adsorbing psoralens and psoralen photoproducts. The removal process is particularly suitable for use with platelet concentrates and plasma because the process does not have a significant adverse effect on clotting factor function. The methods and devices can be incorporated with apheresis systems and other devices and procedures currently used to process blood products for transfusion.

Methods and devices for the removal of psoralens from blood products

Containers and methods for making containers are disclosed. The containers include a chamber and a pouch fixed within the chamber. During manufacture, the open edges of the pouch are sealed between the walls of the container by a seal defining, in part, the peripheral edge of the chamber.

Plastic containers having inner pouches and methods for making such containers

Membranes and methods for making membranes are disclosed. The membranes include a polymeric matrix and a particulate material immobilized within the matrix. The membranes may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.

Apparatus, membranes and methods for removing organic compounds from a

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Concord, CA, United States of America

Derek J Hei