Tocagen Inc.

Denovo Biopharma LLC

Derek G Ostertag

Douglas J Jolly

Harry E Gruber

Amy Lin

Omar D Perez

Joan M Robbins

Tiffany Huang

Daniel J Hogan

Ryan Burnett

Andrew Hofacre

Amy H Lin

This disclosure provides modified recombinant retroviruses comprisings containing a 2A-peptide or peptide-like coding sequence operably linked to a heterologous polynucleotide. The disclosure further relates to cells and vector expressing or comprising such vectors and methods of using such modified vectors in the treatment of disease and disorders.

Recombinant vectors comprising 2A peptide

The disclosure provides vectors for treating cancers, method of producing such vectors and methods of use of the vectors.

Retroviral vector having immune-stimulating activity

This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

Compositions comprising gamma retrovirus vectors and methods of treating proliferative disorders

This disclosure relates to a combination therapy of chemotherapeutics and/or radiosensitizing agents with a replication competent viral vectors for treating cell proliferative disorders and chemotherapeutic treatments. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

Cancer combination therapy and recombinant vectors

Growing community of inventors

San Diego, CA, United States of America

Derek G Ostertag