Purdue Research Foundation

Derek Doorneweerd

Philip Stewart Low

Walter A Henne

Cagri Abdullah Savran

David H Thompson

Alexander Wei

Chun-Li Chang

Ronald George Reifenberger

Youngsoon Kim

Ghanashyam S Acharya

Wei He

Yeong E Kim

Walter Anthony Henne, Jr

David Brownholland

Avijit Kumar Adak

David Lyvers

Kulbhushan Durugkar

Rajendra P Bandari

Rajesh Kumar Pandey

Alexei Leonov

Systems and methods for rapid and ultrasensitive detection of target biomolecules in a sample are presented. The detection of biomolecules is achieved through a synergistic use of immunoseparation and diffractometry, and the formation of antibody-biomolecule-ligand sandwich complexes that form diffraction gratings. Characteristic diffraction patterns are then produced upon illumination of the diffraction gratings with light. The diffraction patterns can be used to detect very low amounts of biomolecules present in the sample.

Ultrasensitive detection of biomolecules using immunoseparation and diffractometry

Pathogens are detected through the use of mutation-resistant ligands.

Pathogen detection

The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formulaAb-X

Multiphoton in vivo flow cytometry method and device

Growing community of inventors

West Lafayette, IN, United States of America

Derek Doorneweerd