Leland Stanford Junior University

Cz Biohub Sf, Llc.

Chan Zuckerberg Biohub, Inc.

Derek Croote

Stephen R Quake

Kari C Nadeau

Spyros Darmanis

David N Cornfield

Shirit Einav

Eric Waltari

Makeda L Robinson

Fabio Zanini

Leslie Goo

Krista McCutcheon

Provided are antibodies or antigen binding portions thereof that specifically bind Dengue virus, various compositions of such antibodies or antigen binding portions thereof, and methods of their use. Provided are such antibodies, fragments of such antibodies retaining Dengue virus-binding ability, pharmaceutical compositions including such antibodies or antigen binding fragments thereof, and diagnostic compositions including such antibodies or antigen binding fragments thereof. Also provided are isolated nucleic acids encoding such antibodies, amino acid sequences of such antibodies, and host cells transformed therewith. Additionally, provided are prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the disclosure.

Antibodies against dengue virus and related methods

In one aspect, methods of generating human monoclonal antibodies that specifically binds to an allergen are provided. In some embodiments, the monoclonal antibodies are generated from sequences identified from isolated single B cells from a human subject who is allergic to the allergen.

Methods of isolating allergen-specific antibodies from humans and uses thereof

Identifying human B cells expressing anti-allergen antibodies

Allergen-specific antibodies

Growing community of inventors

Stanford, CA, United States of America

Derek Croote