Bausch-lomb Incorporated

Liquidia Technologies, Inc.

Bausch and Lamb, Inc.

Derek A Schorzman

Joseph C Salamone

Jay Friedrich Kunzler

Daniel M Ammon, Jr

Alexander Ermochkine

Jeffrey George Linhardt

Alexander Ermoshkin

Jacob J Sprague

Ivan M Nunez

Jason K Stanbro

Daniel M Ammon

A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.

Method for producing patterned materials

The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymeric compositions comprise polymerized cationic hydrophilic siloxanyl monomers prepared by the process disclosed herein.

Process for making cationic hydrophilic siloxanyl monomers

The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic random copolymers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized siloxane prepolymer containing pendant cationic and polymerizable groups.

Siloxane prepolymer containing pendant cationic and polymerizable groups

The present invention provides prepolymers based on poly(alkyl ethers) having terminal trifluorovinyl aromatic containing groups and polymers produced from such prepolymers. The prepolymers and polymers are useful as biomedical devices such as contact lenses or intraocular lenses.

Trifluorovinyl aromatic containing poly(alkyl ether) prepolymers

The present invention provides copolymer having repeating units based on polyoxyalkylene radicals, polysiloxane radicals and perfluorocyclobutane radicals. The copolymers are useful as biomedical devices such as contact lenses or intraocular lenses.

Perfluorocyclobutane copolymers

This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.

Synthesis of cationic siloxane prepolymers

Matrix controlled diffusion drug delivery systems are described herein which are based on one or more silicon-containing monomers of the general formula: wherein L, X, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.

Drug delivery system based on cationic siloxanyl macromonomers

Matrix controlled diffusion drug delivery systems based on one or more silicon-containing monomers of the general formula: wherein L, X, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.

Drug delivery systems based on catonic siloxanyl macromonomers

The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymer compositions comprise polymerized fluorinated polyether monomer end-capped with ethylenically unsaturated cationic hydrophilic groups.

Fluorinated poly(ether)s end-capped with polymerizable cationic hydrophilic groups

The present invention relates to hydrophilic dicationic siloxane prepolymers with one polymerizable vinyl moiety instead of two polymerizable vinyl moieties, resulting in contact lenses and/or biomedical devices with reduced cross-link density and modulus without detracting from other properties.

Cationic end-capped siloxane prepolymer for reduced cross-link density

Biomedical devices are provided herein which are formed from a polymerization product of a monomeric mixture comprising (a) one or more esterified aminoalcohol monomers; and (b) one or more biomedical device-forming monomers.

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Ellicott City, MD, United States of America

Derek A Schorzman