Industrial Technology Research Institute

China Medical University

Taichung Veterans General Hospital

Der-Yuan Chen

I-Horng Pan

Shu-Fang Wen

Hsin-Chieh Wu

Hsin-Jan Yao

I-Huang Lu

Chi-Chien Lin

Ming-Han Li

Ching Te Lu

Tsai-Ling Liao

Joung-Liang Lan

Chin-An Yang

The invention relates to method of diagnosis a subject suffering from Adult-onset Still's disease and further to determine the disease course of the subject suffering from Adult-onset Still's disease.

Method for diagnosis and subtyping of adult onset Still's disease

The present invention discloses a new biomarker miR-134, miR-223, or IL-18, which is positively correlated with AOSD and activities thereof. By detecting the expression level of at least one biomarker in a sample, an effect of detecting the risk and prognosis of a sample provider suffering from a disease is achieved.

Method for detecting the risk and prognosis of adult-onset Still's disease

The disclosure provides a method for modulating Th17 cells, including: administering an(also namedor) extract to a subject in need thereof, wherein theextract has an effect of modulating Th17 cells. Theextract may include a fruiting body extract ofor a mycelium extract of

Method for modulating Th17 cells and method for treating a disease related to modulation of Th17 cells

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Taichung, Taiwan

Der-Yuan Chen