The United States of America, As Represented by the Secretary, Department of Health and Human Services

Deqi Xu

Dennis J Kopecko

John O Cisar

The invention relates toTy21a comprising core-linkedserotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encodingserotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.

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Compositions and methods for protecting a susceptible host against an infection ofare disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.

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Columbia, MD, United States of America

Deqi Xu