Tsinghua University

Aviva Biosciences Corporation

Capitalbio Corporation

Captialbio Corporation

Capital Biochip Company Ltd

Depu Chen

Jing Cheng

Junquan Xu

Litian Liu

Yuxiang Zhou

Lianghong Guo

Guangshun Yi

Baoquan Sun

Xiaobo Wang

Lei Wu

Jia Wang

Xin Xie

David M Rothwarf

Guoliang Tao

Weiping Yang

Ken Chen

Wei Shao

Xiaoshan Zhu

Zewen Liu

Wenzhang Xie

Xuezhong He

Zhiming Li

Zhimin Tan

Huachang Lu

Xu Zhang

Mingxian Huang

Wenjun Yang

Weiyang Fei

Yue Ge

Mingxiang Huang

Xiumel Liu

Xiumei Liu

This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.

Fluorescent magnetic nanoparticles and process of preparation

This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.

Microdevice containing photorecognizable coding patterns and methods of using and producing the same

This invention relates generally to the field of cell seperation. In particular, the invention provides processes for isolating a target cell, cellular organelle or virus from a sample, using inter alia, nonspecific binding between a target cell, cellular organelle or virus with a magnetic microbead modified to comprise hydroxyl, carboxyl or epoxy groups.

Magnetism based rapid cell separation

This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.

Microdevices having a preferential axis of magnetization and uses thereof

Nanometer-scaled up-converting fluoride phosphor particles and processes of making them are disclosed. In the process, an aqueous solution consisting of soluble salts of rare-earth metal ions at a molar ratio of (yttrium, lanthanum or gadolinium): ytterbium:(erbium, holmium, terbium or thulium)=(70-90):(0-29):(0.001-15) is mixed a rare-earth metal chelator and a soluble fluoride salt to form precipitates, which are then annealed at an elevated temperature to produce nanometer-scaled up-converting fluoride phosphor particles. The particle size is between 35 nm and 200 nm, and can be controlled by the amount of the metal chelator added to the solution. The nanometer-sized particle is applicable to many biological assays.

Nanometer-sized up-converting phosphor fluoride particles and process of preparation

This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.

Individually addressable micro-electromagnetic unit array chips

Growing community of inventors

Beijing, China

Depu Chen