Daewoong Pharmaceutical Co., Ltd.

Deok Ki Eom

Yeon Im Lee

Chun Ho Lee

Sang Shin Lee

Jun Hee Lee

Sang Ho Lee

Joon Seok Park

Ji Duck Kim

Mi Ryeong Han

Kyung A Yu

Jeong-Taek Shin

Keuk-Chan Bang

Ji Sung Yoon

Jeong-Hyun Son

Ha Nee Seo

Seung Chul Lee

Keuk Chan Bang

Youn Jung Yoon

Jeong Hyun Son

Eun Ji Koh

Hye Ryun Shin

Wol Young Kim

Jaehyun Jung

Jeong Taek Shin

The present disclosure relates to a novel heterocyclic amine derivative represented by the following Chemical Formula 1 and a pharmaceutical composition comprising the same, and the compound according to the present disclosure can be usefully used for the prevention or treatment of autoimmune diseases or cancers.

Heterocyclic amine derivative and pharmaceutical composition comprising same

The present disclosure relates to a manufacturing method for 4-methoxypyrrole derivatives. The embodiment of the present disclosure is useful for industrial mass production of 4-methoxypyrrole derivatives, because the process efficiency and yield are improved, and the use of hazardous reagents and environmental polluting reagents is avoided.

Manufacturing method for 4-methoxypyrrole derivatives

The present invention relates to a novel 1H-pyrazolopyridine derivative and a pharmaceutical composition containing the same. The 1H-pyrazolopyridine derivative and the pharmaceutical composition containing the same can be usefully used for the prevention or treatment of autoimmune diseases or cancer.

1H-pyrazolopyridine derivative and pharmaceutical composition comprising the same

The present invention relates to a method for preparing intermediates of 4-methoxypyrrole derivatives. The preparation method according to the present invention has advantages that a high-temperature reaction is not required as a whole, inexpensive and non-explosive reagents are used instead of (trimethylsilyl)diazomethane, and further an intermediate of 4-methoxy pyrrole derivatives can be prepared as a whole at a high yield.

Method for preparing intermediate of 4-methoxypyrrole derivative

The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or. Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.

4-methoxy pyrrole derivatives or salts thereof and pharmaceutical composition comprising the same

The present invention provides tetrahydrocyclopentapyrrole derivatives that can be used for preventing or treating peptic ulcer, gastritis or reflux esophagitis, a method for preparing the same, and a pharmaceutical composition containing the same.

Tetrahydrocyclopentapyrrole derivatives and a method for preparing the same

Disclosed are a sulfonylindole derivative useful for the prevention or treatment of peptic ulcer, gastritis or reflux esophagitis, a method of preparing the same, and a pharmaceutical composition containing the same.

Sulfonylindole derivatives and method for preparing the same

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Gyeonggi-do, South Korea

Deok Ki Eom