Emd Millipore Corporation

Dennis Wong

Brian Pereira

Elias G Noukas

Aaron Burke

Martin Morrissey

Michael Felo

Jean-Louis Weissenbach

James E Kelly

John Saragosa

Steve Mello

Kristin Prescott

Jean-Louise Weissenbach

A feed bag construction is provided comprising a feed bag, a first conduit sealed to the feed bag, a second conduit sealed to the interior of the feed bag for supplying wash reagent to the feed bag and a one piece cap that is removably mounted on the first conduit. The first conduit is provided with a hand operated butterfly valve to open or close the conduit.

Feed bag construction

A disposable container for fluid having an inlet and an outlet is provided. The container has a vortex breaker having a solid surface adapted to initially direct fluid away from the outlet and then through the outlet positioned adjacent the container outlet.

Container having vortex breaker and system

Tangential flow filtration device is provided wherein liners are provided between the filtration element and the top and bottom holders or manifolds. The liners incorporate the flow channels and inlet and outlet ports, as well as a sensor mount. The liners are made of an inexpensive material and therefore are disposable after a single use, making it more cost effective to dispose of them than to clean the conventional manifolds. The sensor mount accommodates a removable sensor, and isolates it from the fluid path.

Disposable tangential flow filtration liner with sensor mount

The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

Biomaterial freezing

Biocontainer with integrated temperature sensor

A process bag container is provided comprising a flexible bag, at least one inlet sealed to the bag, and an outlet. A probe housing for a probe construction is sealed to the bag. Preferably, the probe housing extends at least partway into the bag interior and is connected to a cable for power and data transmission that runs along the outer surface of the bag to the top of the bag or its support container. The probe construction is adapted to monitor the composition of a reagent in the bag as well as the environment within the bag. A mixer is positioned within the bag to effect mixing of reagents in the bag.

Growing community of inventors

Dedham, MA, United States of America

Dennis Wong