American Cyanamid Company

Other

Dennis W Powell

Jay Donald Albright

William A Hallett

Minu D Dutia

Dan Maarten Berger

Rolf Paul

John P Dusza

John F Poletto

Daniel B Moran

Diane H Boschelli

Mark E Salvati

Ralph G Child

Adolph E Sloboda

Nancy H Eudy

Leslie H Sutherland

The invention provides novel substituted dibenzothiophenes of Formulae (I), (II), (III) and (IV) which have antiangiogenic activity and further provides a method using substituted dibenzothiophenes of Formula (V) as antiangiogenic agents.

Substituted dibenzothiophenes having antiangiogenic activity

Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.

MDR reversal agents

Substituted quinolinecarboxylic acids useful in the treatment of arthritis by inhibiting the progressive joint deterioration characteristic of arthritic disease and for inducing immunosuppression are disclosed. Methods of synthesis and use of the novel compounds are also disclosed.

Substituted quinolinecarboxylic acids

Novel organic compounds which are N-substituted-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamdies , carbamates and ureas which are useful as anxiolytic or antiepileptic agents, methods of using the compounds, compositions of matter containing them as the active ingredient and processes for their production.

N-substituted

Substituted 4-quinoline-carboxylic acids useful in the treatment of arthritis and inhibition of progressive joint deterioration are disclosed together with methods of use and synthesis thereof.

2-Phenyl-4-quinoline carboxylic acids

Novel organic compounds which are N-substituted-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides , carbamates and ureas which are useful as anxiolytic or antiepileptic agents, methods of using the compounds, compositions of matter containing them as the active ingredient and processes for their production.

N-substituted-N-[3-(1,2,4-triazolo-[4,3-b]pyridazin-6-yl

N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]a

This invention concerns novel imidazo[1,2-b]-pyridazines and their use as agents for treating anxiety.

Imidazo[1,2-b]pyridazines

This disclosure describes novel substituted 1,2,4-triazolo[4,3-a]pyridines which possess anxioltic activity.

Growing community of inventors

Greenwich, CT, United States of America

Dennis W Powell