Celsion Corporation

Boston Scientific Corporation

Dennis Smith

John Mon

Alan J Fenn

A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30&#xb0; C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30&#xb0; C. being circulated adjacent the bodily conduit to maintain the warmth in its walls and the compression of the tissue to be treated enables a natural stent to be formed that remains after the catheter and compression balloon is removed.

Device and method for treatment of tissue adjacent a bodily conduit by thermocompression

Device for treatment of tissue adjacent a bodily conduit by thermocompression

A monopole phased array thermotherapy applicator radiating radiofrequency energy for inducing a temperature rise in a target within a body includes a plurality of monopole elements each for transmitting electric-field radiation; a metallic waveguide with an RF reflecting ground plane surface with a plurality of circular holes for mounting the monopole elements where the metallic waveguide forms an aperture for receiving a body to be treated; a waveform generator providing a source of electric field coupled to each monopole radiating element through a respective phase and power weighting network; at least one electric field probe positioned on a skin surface of the body for detecting electric field radiation from the plurality of monopole elements; and a controller circuit coupled to the electric field probe received feedback signals to adjust the phase and power delivered to the plurality of monopole elements so that one or more adaptive nulls are formed on the surface of the body and a focus is formed at the target tissue to be treated with thermotherapy.

Monopole phased array thermotherapy applicator for deep tumor therapy

A method and apparatus that increases safety when employing externally focused adaptive phased array microwave thermotherapy (hyperthermia) for breast cancer treatment include microwave absorbing pads and metallic shielding to prevent undesired or stray surface tissue heating and to cushion the breast from mechanical pressure during breast compression. The microwave absorbing pads are attached on the top of the microwave waveguide thermotherapy applicators and on top of the breast compression paddles. A metallic-shielding strip mounted across the top portion of the microwave applicator aperture acts to block microwave radiation from illuminating the base of the breast and chest wall area. The patient treatment table utilizes a metallic shield to shield the body from stray microwave radiation. Combined E-field and temperature sensors within a single catheter are used to require only a single minimally invasive skin entry point for E-field focusing and measurement of the tumor temperature. Breast compression is maintained for a period of time following microwave-induced heating to accumulate additional equivalent thermal dose. Treatments incorporating the safety improvements include thermotherapy for early-stage breast carcinomas, locally advanced breast cancer, ductal carcinoma in-situ, and benign breast lesions.

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Ellicott City, MD, United States of America

Dennis Smith