Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Dennis R Carter

David J Schurman

David Myung

Curtis W Frank

Lampros Kourtis

R Lane Smith

Stuart Barry Goodman

Laura Hartmann

Robert Lane Smith

Wilson C Hayes

Gary S Beaupr&eacute;

Jay A Mandell

Gary S Beaupre

The present invention relates generally to the field of fans and heaters. More specifically, the present invention relates to a portable oscillating fan platform device. The device is comprised of a base that is further comprised of a rotating platform, a battery, a motor and a processor. A non-oscillating fan or heater can be placed on the rotating platform wherein the device can then be powered on and the platform can rotate, thereby rotating the fan or heater on the platform. The device may further have at least one button that allows a user to power the device on/off and may also allow a user to control the spinning of the platform. The base may further be comprised of a power cord, USB charging port, and female power receptacle that can be used to supply power to the fan/heater on top of the device.

Portable oscillating fan platform device

A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within to joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.

Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling

An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

Hydrogel arthroplasty device

A method for in vivo, ex vivo and in vitro regeneration of cartilage, collagen and bone remodeling by intermittently applied hydrostatic pressure consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The intermittent hydrostatic pressure is applied at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.

Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage

A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene, expression of growth factors that are inhibitory to type II collagen expression.

Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling

Novel prostheses, particularly femoral prostheses, are provided. The subject devices are characterized by the presence of a curvilinear collar. Also provided are methods of implanting a prosthesis in a manner sufficient to provide for a pressure profile at the collar interface in which the pressure increases from the endosteal to the periosteal surface of the bone.

Prostheses having curvilinear collars

The invention presents a method and device for increasing the fracture resistance of a bone tissue to a traumatic force. The method includes the step of selecting a nonphysiological impulse force having a location and direction resembling that of the traumatic force, but having a magnitude significantly smaller than the magnitude of the traumatic force. The impulse force is then repeatedly applied to the bone tissue, thereby stimulating the bone tissue to grow bone mass in critical areas where stresses from the traumatic force are largest. A device for applying the method includes an impulse force applicator for repeatedly applying the impulse force and a positioner for positioning the impulse force relative to the bone tissue.

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Stanford, CA, United States of America

Dennis R Carter