Eli Lilly and Company

Dennis R Berry

Robert L Hamill

Manuel Debono

Raymond C Yao

Anne H Dantzig

R Michael Molloy

Bernard J Abbott

Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.

A87689 compounds

A87689 compounds employed as a phospholipase A.sub.2 (PLA.sub.2)

Amycolatopsis mediterranei strains useful to prepare A87689 compounds

The microorganism Streptomyces capillispira, NRRL 12279, produces an enzyme which deesterifies cephalosporin methyl esters.

Enzymatic deesterification of cephalosporin methyl esters

Growing community of inventors

Greenwood, IN, United States of America

Dennis R Berry