The Procter Gamble Company

Dennis P Riley

Paul Elliott Correa

James R Tucker

John T Rotruck

Mark M Anderson

Fluronaphthalene chromium tricarbonyls useful as hydrogenation catalysts are disclosed. Compositions suitable for hydrogenation comprise glycerides, nonglyceride esters, or mixtures thereof having polyunsaturated fatty acid residues, in particular polyunsaturated vegetable oils and those containing methyl linoleate. After being placed in a reactor having an inert inner surface, the polyunsaturated fatty acid residue-containing composition is contacted with hydrogen in the presence of the fluoronaphthalene chromium tricarbonyl to effect hydrogenation of the polyunsaturated fatty acid residues.

Fluronaphthalene chromium tricarbonyls useful as hydrogenation catalysts

Chromium(III) tris-acetylacetonate, a coordinatively saturated, stable chromium(III) compound provides a dietary chromium supplement for humans and lower animals and is a useful hypoglycemic pharmaceutical agent for treating diabetes, especially when used in conjunction with insulin therapy.

Chromium acetylacetonate as a dietary supplement and pharmaceutical agent

A process for the catalytic oxidation of nonaromatic tertiary amines to the respective amine oxides is disclosed. An aqueous solvent system containing the tertiary amine is formed with an initial pH about equal to or greater than the pKa of the tertiary amine. This aqueous system is contacted with gaseous molecular oxygen at an oxygen partial pressure of at least about 50 psi and a temperature of at least about 80.degree. C. in the presence of certain octacyanomolybdate or iron (III) salts. The resulting oxidation converts the tertiary amine to the respective amine oxide in good yield.

Oxidation of tertiary amines using octacyanomolybdate or iron (III)

The chiral phosphine ligand (R)-1,2-bis(diphenylphosphino)-1-cyclohexylethane, when complexed to Rh(I), functions as a superior chiral hydrogenation catalyst. The chiral phosphine ligand is more stereochemically rigid than previous compounds; consequently, virtually optically pure materials can be produced from the chiral hydrogenation of prochiral compounds using the catalyst of this invention. This catalyst is especially useful in the chiral hydrogenation of alpha-acylamido acrylic acids.

Rhodium-phosphine chiral hydrogenation catalysis of acetophenone,

Rhodium (1) complexes containing the chiral phosphine ligand (R)-1,2-bis(diphenylphosphino)-1-cyclohexylethane which are useful as chiral hydrogenation catalysts. These catalysts are especially useful in the chiral hydrogenation of alpha-acylamido acrylic acids.

Rhodium complexes containing chiral phosphine ligands useful as

The chiral phosphine ligand (R)-1,2-bis(diphenyl-phosphino)-1-cyclohexylethane, when complexed to Rh(I), functions as a superior chiral hydrogenation catalyst. The chiral phosphine ligand is more stereochemically rigid than previous compounds; consequently, virtually optically pure materials can be produced from the chiral hydrogenation of prochiral compounds using the catalyst of this invention. This catalyst is especially useful in the chiral hydrogenation of alpha-acylamido acrylic acids.

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Forest Park, OH, United States of America

Dennis P Riley