Redshift Bioanalytics, Inc.

Dennis Merrill

Jinhong Kim

In illustrative embodiments, matched optical filters, and methods and systems for using matched optical filters for acquiring infra-red transmission spectra of liquid analytes in very highly absorbing reference solutions are disclosed herein. The matched optical filters compensate for the very high absorbance of the reference solution by filtering out at least a portion of coherent light from a tunable infra-red optical laser to a substantially inverse manner to the absorbance of the reference solution. The matched optical filter may be adjusted to compensate for differences in laser gain across a spectral region of interest where the differential transmission at each wavelength may vary by more than 150 times across the operating range. Thus, the matched optical filters make it possible to obtain spectra of the liquid analyte that may have several orders of magnitude lower absorbance than the reference solution.

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Burlington, MA, United States of America

Dennis Merrill