Quest International B.v.

Dennis K Taylor

Derek H Barton

Chi-Lam Tse

Shyamal I Parekh

Preparation of a methyl ketone intermediate useful in the synthesis of (-)-dodecahydro-3a,6,6, 9a-tetramethyl-naphtho(2,1-b) furan by subjecting (-)-sclareol to ozonolysis in the presence of iodine or iodine-containing compound. The intermediate can be converted to (-)-dodecahydro-3a,6,6,9a-tetramethyl-naphtho(2,1-b) furan by Baeyer-Villiger oxidation followed by reduction of the resulting product in the presence of a Lewis acid.

Production of (-)dodecahydro-3a,6,6,9a-tetramethyl-naphtho[2,1-b] furan

Synthesis of (-)-dodecahydro-3a,6,6,9a-tetramethyl-naphtho(2,1-b)furan from sclareol in a three-stage process.

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College Station, TX, United States of America

Dennis K Taylor