The Invention Science Fund I LLC

Elwha LLC

Gearbox LLC

Searete LLC

Deep Science, LLC

Somne LLC

Seavete LLC

Dennis James Rivet, Ii

Roderick A Hyde

Lowell L Wood, Jr

Eric Leuthardt

Muriel Y Ishikawa

Victoria Y H Wood

Michael A Smith

Clarence T Tegreene

Jordin T Kare

Edward Stuart Boyden

Elizabeth A Sweeney

Nathan P Myhrvold

Edward K Y Jung

Thomas A Weaver

Charles Whitmer

Robert Samuel Langer

Robert W Lord

Gregory J Della Rocca

Daniel Hawkins

Parag Jitendra Parikh

Terence Myckatyn

Joshua S Shimony

Ralph G Dacey, Jr

Mahalaxmi Gita Bangera

Erez Lieberman

Mark A Malamud

Royce A Levien

John D Rinaldo, Jr

Richard T Lord

Jeffrey A Bowers

Philip Andrew Eckhoff

Stephen L Malaska

Paul G Allen

Hon Wah Chin

Bran Ferren

Michael Baym

Roy P Diaz

Kenneth G Caldeira

Glenn B Foster

Sharon L Wolda

W Daniel Hillis

Leif T Stordal

Jeffrey John Hagen

Ed Harlow

Eun Young Hwang

Tony S Pan

Gary L McKnight

Joshua L Dowling

Erez Lieberman Aiden

Paul Santiago

Todd J Stewart

Katherine A Sharadin

Katherine E Sharadin

Suzanne Kathleen Scheele

An embodiment of a system for treating sleep apnea includes a collar, pump, motor, sensor, memory, and controller, which is configured to store, in the memory, information related to sleep-apnea events or sleep-apnea treatment, experienced by the subject. For example, the controller can obtain, and store in the memory, information related to sleep-apnea events, and the controller, or another computing system, can correlate this information with the subject's lifestyle choices, and can recommend lifestyle changes to improve the subject's sleep apnea. Furthermore, the controller can obtain and store, in the memory, information related to usage and settings of the sleep-apnea system, and the controller, or another computing system, can correlate this information with the subject's wellbeing, and can recommend changes in the usage or the settings of the sleep-apnea system that can improve the subject's wellbeing.

Obtaining, with a sleep-apnea device, information related to sleep-apnea events and sleep-apnea treatment, and correlating sleep apnea events and sleep-apnea treatment with subject lifestyle and wellbeing

Configuration technologies for apportioning resources and communicating indications of potential or actual incentives based on one or more measurements or other objective indications that therapeutic components have been administered to an individual, other attributes of the therapeutic components or the individual, or other such determinants. Techniques for apportioning resources cost-effectively (between providers and other parties, e.g.) and for facilitating or handling implementations thereof or output therefrom.

Cost-effective resource apportionment technologies suitable for facilitating therapies

An embodiment of a system for treating sleep apnea includes a collar, a pump, a motor, a sensor, and a controller. The collar is configured to maintain an airway of a subject open while the subject is sleeping by applying, to a throat of the subject, a negative pressure having a magnitude, and the pump is configured to generate the negative pressure. The motor is configured to drive the pump, and the sensor is configured to generate a sense signal that is related to a degree to which the airway is open. And the controller is configured to vary the magnitude of the negative pressure in response to the sense signal. For example, one or more of the pump, motor, sensor, and controller can be secured to the collar such that the system is self-contained, i.e., the entire sleep-apnea system can be worn by the subject.

Treating sleep apnea with negative pressure

Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.

Tubular nanostructure targeted to cell membrane

Structures and protocols are presented for signaling a status or decision (processing or transmitting a medical record or other resource, e.g.) conditionally. Such signaling may be partly based on one or more symptoms, regimen attributes, performance indicia (compliance indications, e.g.), privacy considerations (patient consent, e.g.), contextual considerations (being in or admitted by a care facility, e.g.), sensor data, or other such determinants. In some contexts this may trigger an incentive being manifested (as a dispensation of an item, e.g.), an intercommunication (telephone call, e.g.) beginning, a device being configured (enabled or customized, e.g.), data distillations being presented or tracked, or other such results.

Evidence-based healthcare information management protocols

A system can perform the following procedure as part of a plan to treat sleep apnea, according to an embodiment. The system monitors a degree to which an airway of a subject is open, and monitors a condition that is related to the degree to which the airway is open. The system also correlates the condition to the degree to which the airway is open, and generates a data structure that represents the correlation between the condition and the degree to which the airway is open. This system can allow a sleep-apnea-treatment system to operate in a closed-loop mode, i.e., to monitor a level of sleep apnea in a subject by monitoring the correlated condition, and to treat the subject in a manner that the treatment system deems appropriate for the level of sleep apnea that the treatment system determines that the subject is experiencing.

Correlating a condition of a subject with a degree of sleep apnea being experienced by the subject

Structures and protocols are presented for signaling a decision (processing or transmitting a medical record or other resource, e.g.) conditionally, at least partly based on one or more performance indicia (excess hospital readmissions, e.g.) or therapeutic determinants (prior success, e.g.) or privacy considerations (patient consent, e.g.).

An active wearable system includes a one or more positioning elements configured as a torso support and/or other wearable item, one or more sensors for sensing motion, posture, or gait of a subject, and at least one of force applying elements for applying force to selected regions of a body of a subject, and feedback device and other actuators, under the control of control circuitry responsive to sensed motion, posture or gait of the subject. In an aspect, force is applied according to spatial or temporal patterns. Related devices and methods are described.

Sensor-based control of active wearable system

Systems, devices, and methods are described for tracking, registering, etc. of medical staff, patients, instrumentation, events, or the like according to a treatment staging plan. For example a medical apparatus includes a right-patient verification device having an interrogation interface device that elicits at least one of identification data, authorization data, or treatment plan data from a medical procedure authorization device associated with a patient; and a right-site verification device that generates patient-specific treatment staging data consistent with the at least one of the identification data, the authorization data, or the treatment plan data.

Electronically determining compliance of a medical treatment of a subject with a medical treatment plan for the subject

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Portsmouth, VA, United States of America

Dennis James Rivet, Ii