Lifeline Scientific, Inc.

Other

Organ Recovery Systems, Inc.

Dennis J Steibel

Richard T Fraser

Dickon Isaacs

David C Kravitz

John Brassil

Andrew Burroughs

Kelvin G M Brockbank

Douglas A Schein

Donald R Owen

Stanley Harris

Steven Dominguez

Christopher G Curtis

Kelvin Gm Brockbank

Andrews Burroughs

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

Apparatus and method for maintaining and/or restoring viability of organs

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

Method for controlling perfusion of an organ

Method of determining transport and/or storage parameters for maintaining viability of an organ

A system for monitoring body functions from patients at remote locations that includes an event monitor attached to the patient including sensors attached to relevant parts of the patient for monitoring body functions. The system also includes a central monitoring station including a server having a memory attached thereto; and, a communication link between the event monitor and the central monitoring station. The method of this invention includes the steps of sensing the monitored body function by means of sensors attached to the patient. If any irregularities are detected, data indicative of the monitored body function is recorded and is automatically transmitted to the central monitoring station. The patient is located by means of GPS data; and a physician and the nearest hospital are notified. An attending physician may log onto the central monitoring station and observe real-time data received from the patient. Commands may be relayed to a medication dispensing device to aid in the immediate treatment of the patient.

System and method for monitoring body functions

Growing community of inventors

Lake Zurich, IL, United States of America

Dennis J Steibel