Louisiana State University and Agricultural & Mechanical College

South Rampart Pharma, LLC

University of Alcala De Henares

Other

The Foundation for the Lsu Health Sciences Center

University of Alcala De Hernares

Dennis J Paul

Nicolas G Bazan

Julio Alvarez-Builla

Hernan Bazan

Carlos Sunkel

Julio Alvarez-Builla Gomez

Harry J Gould

Carolina Burgos Garcia

Carolina Burgos

Iii Harry J Gould

Methods are provided for targeting cancer cells that over-express voltage-gated sodium channels (VGSCs or 'sodium channels') and causing osmotic lysis of these cancer cells by initially inhibiting the sodium, potassium-adenosine triphosphatase (Na, K-ATPase or 'sodium pump'), and then stimulating the VGSCs by pulsed magnetic field gradients to cause sodium and water to enter the cancer cells.

Targeted osmotic lysis of malignant cancer cells using pulsed magnetic field gradients

This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain and fever.

Compositions and methods for ameliorating pain and reducing fever

This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain.

Compositions and methods for ameliorating pain

A targeted osmotic lysis (TOL) of tumor cells that over-express voltage-gated sodium channels (VGSCs) has been developed that uses a combined therapy of a drug that blocks sodium, potassium-adenosine triphosphatase (Na, K-ATPase) that is then followed by an activation of VGSCs, for example, by electrical or pharmacological stimulation. Activation of VGSCs conducts sodium into the cancer cells in much greater amounts than non-cancer cells. Water follows this sodium gradient into the cancer cells, causing swelling and lysis. Because non-cancerous cells do not over-express VGSCs, less sodium and less water will enter the cells, and the non-cancerous cells will not lyse. This method is applicable to all cells that over-express VGSCs, including, but not limited to, highly invasive breast cancer, prostate cancer, small cell lung cancer, non-small cell lung carcinoma, lymphoma, mesothelioma, neuroblastoma, and cervical cancer.

Targeted osmotic lysis of cancer cells

The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with caffeine and an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency and are free from antipyretic activity, do not suppress blood coagulation, and have little hepatotoxic effect.

Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine

The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency, do not suppress blood coagulation, and have little hepatotoxic effect.

Growing community of inventors

New Orleans, LA, United States of America

Dennis J Paul