Pfizer Corporation

Other

Dennis J Hoover

Judith L Treadway

William H Martin

Robert L Rosati

Bernard Hulin

Ronald Thure Wester

Patrick Robert Verhoest

Christopher John Helal

John Michael Humphrey

Douglas Phillips

Bruce A Lefker

Keith Michael DeVries

Philip D Hammen

Darrell E Fox

W Ross Tracey

Thomas L Ison

Jeffrey B Jorgensen

A reconfigurable RV is provided, having a multi-section wall separating a living quarters and a garage, that wall being vertically adjustable by elevation of the living quarters floor to selectively move between multiple modes of use, including full down, loft, and full up. The vertical adjustment of the wall permits changes in the usable area of the garage floor, according to the ceiling height needed in the garage and living quarters concurrently.

Reconfigurable recreational vehicle

The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.

Heteroaromatic quinoline compounds

This invention relates to certain indole-2-carboxamides of formula (I) and the pharmaceutically acceptable salts and prodrugs thereof, wherein Ris carboxy, (C-C)alkoxycarbonyl, C(O)NRRor C(O)R, useful as inhibitors of glycogen phosphorylase, methods of treating glycogen phosphorylase dependent diseases or conditions with such compounds and pharmaceutical compositions comprising such compounds.

Substituted N-(indole-2-carbonyl) -amides and derivatives as glycogen phosphorylase inhibitors

This invention relates to certain indole-2-carboxamides of formula (I) and the pharmaceutically acceptable salts and prodrugs thereof, wherein R is carboxy, (C -C )alkoxycarbonyl, C(O)NR R or C(O)R , useful as inhibitors of glycogen phosphorylase, methods of treating glycogen phosphorylase dependent diseases or conditions with such compounds and pharmaceutical compositions comprising such compounds.

Substituted N-( indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors

The present invention provides novel processes for preparing 3(S)-&lsqb;(5-chloro-1H-indole-2-carbonyl)-amino&rsqb;-2(R)-hydroxy-4-phenyl-butyric acid. Also provided are novel intermediates used in those processes. Further, the 3(S)-&lsqb;(5-chloro-1H-indole-2-carbonyl)-amino&rsqb;-2(R)-hydroxy-4-phenyl-butyric acid prepared by the novel processes can be further reacted to yield known indole 2-carboxamides and derivatives thereof possessing glycogen phosphorylase inhibitory activity, which are useful in the treatment of mammals, especially human beings, having glycogen phosphorylase dependent diseases or conditions.

Processes and intermediates for preparing 3(S)-&lsqb;(5-chloro-1H-indole-2-carbonyl)-amino&rsqb;-2(R)-hydroxy-4-phenyl-butyric acid

Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors

Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors

Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as

A method of preventing non-cardiac tissue damage resulting from ischemia and/or hypoxia, comprising administering to a patient in need of such treatment an effective amount of an glycogen phosphorylase inhibitor.

Method of reducing tissue damage associated with non-cardiac ischemia

This invention relates to compounds of the formula ##STR1## wherein Q, Z, D, E, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined as below, and the pharmaceutically acceptable salts thereof are disclosed. The compounds are useful as antihypertensive agents.

Orally active renin inhibitors

Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.

Nor-statine and nor-cyclostatine polypeptides

Polypeptides and derivatives thereof containing homocyclostatine and cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.

Homocyclostatine and cyclostatine containing polypeptides as

Polypeptides containing fluorinated cyclostatine derivatives as antihypertensive agents.

Growing community of inventors

Mystic, CT, United States of America

Dennis J Hoover