Terumo Bct, Inc.

Cobe Laboratories, Inc.

Gambro, Inc.

Terumo Bct Biotechnologies, LLC

Caridianbct Biotechnologies, LLC

Caridianbct, Inc.

Kinetic Concepts, Inc.

Dennis J Hlavinka

Daniel A Joseph

Victor D Dolecek

Thomas J Felt

Frank Corbin, Iii

Linda A Taylor

Kestas P Parakininkas

Kirk L Weimer

Mark E Hillam

Rajesh Pareta

Brian M Holmes

Robert W Langley

Brian J Nankervis

Thomas G Dilorenzo

Nathan D Frank

Nathaniel T Johnson

Eric T Hansen

John C Walker

Timothy Michael Taga

Anne Baker Oram

Terrence M Cussen

Robert L White

Raymond P Goodrich

Jon A Dodd

Haralambos P Apostolopoulos

James R Ladtkow

Dennis A Bridges

Keith J Manica

Todd Curtis Green

William G Palsulich

Taylor Polodna

Steven H Johnson

Mark E Jones

Darryl Hudock

Daniel R Clement

Jeremy T Parsons

Raymond Paul Goodrich, Jr

Andrew Gloor

Rylan A Summit

Margaret V Kwiat

Byron W Larson

Peter O'Brien

Alexander Du Nguyen

Jesse Janzen

Nate T Johnson

Michael Lawrence Glover

Daniel T McGinnis

Burt L Swersey

Terry D Boucher

Douglas S Harris

Michael A Martinez

Laura Goodrich

Edward C Wood, Jr

Heather Reddy

James L Zook

Richard M Kenshalo

Daniel McGraw

Luke Edwin Ladtkow

John R Merkling

David Bihm

Dalip Sethi

Luke Edwin Storm

Daniel Mcgraw

Frank Iii Corbin

Edward C Wood

Keith Manica

Raymond Paul Goodrich

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Methods and systems for high-throughput blood component collection

Embodiments are described for treating a fluid, e.g., a biological fluid. The embodiments may include systems, apparatuses, and methods. Embodiments may provide for a flow cell, with a plurality of manipulation elements, through which a fluid is flowed. The fluid may be treated (e.g., exposed to energy) as it moves through the flow cell. In embodiments, the flow cell may be used to inactivate pathogens in the fluid.

Flow cell

A modular cassette is provided for separating a composite fluid into at least two component parts thereof during centrifugation. The modular cassette includes: a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; a fluidic channel configured to provide fluid communication between at least two components of the modular cassette; a heat expanding valve including: a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel; and a heating element configured to actuate the heat expanding valve.

Centrifugal fluid separation device

Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface in some embodiments. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber in a bioreactor, by controlling the movement of a fluid in which a coating agent is suspended, by changing flow rates, by changing flow directions, by rotation of the bioreactor, and/or combinations thereof.

Coating a bioreactor in a cell expansion system

Implementations are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In implementations, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other implementations, the cells may be grown in co-culture with other cells, e.g., hMSC's. In implementations, the cells may include CD34+ cells. A coated membrane includes a membrane having a first coating configured to promote cellular adhesion to the membrane and a second coating that includes a soluble protein moiety.

Cell capture and expansion

Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber, by controlling the movement of a fluid in which a coating agent is suspended. Using ultrafiltration, the fluid may be pushed through the pores of a hollow fiber from a first side, e.g., an intracapillary (IC) side, of the hollow fiber to a second side, e.g., an extracapillary (EC) side, while the coating agent is actively promoted to the surface of the hollow fiber. In so doing, the coating agent may be hydrostatically deposited onto a wall, e.g., inner wall, of the hollow fiber.

Methods and systems for coating a cell growth surface

Provided is a multi-part lyophilization container for lyophilizing a fluid, storing the lyophilizate, reconstituting the lyophilizate, and infusing the reconstituted lyophilizate into a patient, including a method of using same. The container includes a front surface, a back surface, a non-breathable section including a port region, a breathable section including a breathable membrane, and a peelable region including a peelable seal encompassing a boundary between the non-breathable section and the breathable section. The method includes inputting a fluid into a non-breathable section of the container, freezing the fluid, applying, in a lyophilization chamber, vacuum pressure, opening the peelable seal using a pressure differential, applying heat energy, sublimating the fluid and creating a temporary occlusion in a peelable region of the container.

Multi-part lyophilization container and method of use

Fluid flow-through

Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.

Lyophilization container fill fixture, system and method of use

Embodiments relate to systems, chambers, and methods for processing particles by washing, concentrating, and/or treating the particles. Some embodiments provide for the processing of cells that may be in a liquid medium (e.g., a liquid in which the cells were grown) and are processed by being washed and concentrated for later use in research or other therapies.

Three-port chamber for processing particles

Growing community of inventors

Arvada, CO, United States of America

Dennis J Hlavinka