Merck + Co., Inc.

Dennis J Carlo

Arpi Hagopian

Peter J Kniskern

Thomas H Stoudt

Yashwant D Karkhanis

Guadalupe A Limjuco

Karl H Nollstadt

Jesse J Jackson

Robert Z Maigetter

Group B Streptococcus type-specific polysaccharides types I.sub.1, I.sub.b, II and III have been obtained from strains grown in a modified soy bean and yeast medium. These polysaccharides are useful as active or passive streptococcal vaccines.

Group B streptococcal capsular polysaccharides

A high molecular weight capsular polysaccharide from H. influenza type b is an effective immunogenic agent against infection caused by the H. influenza type b bacterium.

Meningitis vaccine

An antigenic, immunogenic, non-toxic complex is obtained from the cell surface of N. gonorrhoeae.

Antigenic complex from N. gonorrhoeae

A vaccine against dental caries is prepared from capsular polysaccharides (one or more strains), of Streptococcus pneumoniae.

Vaccine for dental caries

A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.

E. coli enterotoxin vaccine for veterinary and human use

A sub-cellular antigenic fraction of Bordetella bronchiseptica protects against the incidence and severity of swine atropic rhinitis.

Method of obtaining an antigenic fraction from Bordetella bronchiseptica

A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The polysaccharide was isolated from Group C hexadecyl trimethylammonium bromide cell paste with 1.0M CaCl.sub.2 extraction and purified by phenol extraction, ultracentrifugation at 100,000 g. and ethanol fractionation (30%-45% v/v in ethanol).

High molecular weight meningococcal group C vaccine and method for

Antigenic complex from N. Gonorrhoeae

Swine atropic rhinitis vaccine

Method for preparing high molecular weight meningococcal Group C vaccine

Endotoxin contaminant in meningococcus group A and group C polysaccharide is removed by means of a phosphate containing adsorbent.

Growing community of inventors

South Amboy, NJ, United States of America

Dennis J Carlo